Las Vegas Metro police said an armed man surrendered after a three-hour standoff on a two-story bus that closed the Vegas Strip on Saturday.
Police say the man shot and killed one person and wounded another.
Police evacuated the nearby Cosmopolitan hotel and casino floor shortly before 11 a.m. local time Saturday as a result of the incident. They blocked off pedestrian walkways and several blocks of traffic on the Strip. Guests were allowed back into the casino around 4 p.m. and police slowly reopened roads near the incident.
Despite some reports, there was no confirmed second suspect and it was not an active shooter situation, police added.
"The shooting incident happened on the bus," said Larry Hadfield, a spokesman with Las Vegas Metro police. "We had one single shooting incident with two victims. Both were transported to the trauma center and one is deceased."
Hadfield said the shooter was armed with a handgun and was the only person on the bus before he surrendered.
"This is a single incident and is not deemed to be terrorism related," Hadfield said.
The man was in his 50s and randomly opened fired at passengers, Assistant Sheriff Tom Roberts said.
"He was on the second floor of the bus and started shooting at passengers," Roberts said. "He was delusional and talked about seeing people, so he was definitely not with it and suffered some mental health issues."
Roberts said the man opened fire with a handgun during the police negotiation, but officers did not return fire.
Guests at the hotel were instructed to shelter in their rooms.
Earlier Saturday, three people wearing dress clothing and animal masks robbed a jewelry store inside the Bellagio hotel-casino complex, which is next door, police said. Police said the two incidents are not connected.